BNCT Development Services
Boron neutron capture therapy (BNCT) is an emerging cancer treatment that combines targeted boron compounds and neutron irradiation to destroy tumor cells while selectively sparing healthy tissue. At Alfa Cytology, we provide end-to-end BNCT development services, from boron compound synthesis to preclinical testing, ensuring precision, safety, and regulatory compliance at every step.
Overview of Boron Neutron Capture Therapy (BNCT)
BNCT is an emerging and rapidly developing precision diagnosis and treatment technology in international tumor treatment in recent years. The principle of BNCT is to inject a targeted molecular drug carrying 10B (a stable and non-radioactive natural isotope) into the human body, and the selectivity of the targeted drug causes 10B to concentrate in the tumor tissues with high specificity, and then irradiate the tumor site through a directional low-energy superheated neutron beam. When a neutron is absorbed by the 10B nucleus, a nuclear reaction occurs, this interaction releases high-LET alpha and lithium particles within a cell-sized range (~10 microns), effectively killing cancer cells with minimal impact on surrounding healthy tissue. BNCT holds particular promise in treating glioblastomas, head and neck cancers, and melanomas resistant to other treatments.
Fig.1 The reaction mechanism of BNCT. (Shimizu S, et al., 2023)
Advantages of BNCT
BNCT stands out as an innovative cancer treatment modality, combining precision and efficacy with minimal invasiveness. Its unique mechanism leverages the biological and physical targeting of tumor cells, offering a highly localized and potent therapeutic approach.
Achieves both chemical targeting (boron compounds localize in cancer cells) and physical targeting (neutron beam focused on tumor areas) for accuracy.
- "Cellular Scalpel" Effect
Releases alpha particles and lithium ions at a cellular level, offering a highly potent and localized treatment with reduced risk of drug resistance.
Typically requires only 1-2 sessions, making it faster than traditional therapies.
Effective against challenging cancers (e.g., brain, head and neck, melanoma) and holds potential for other diseases with evolving boron drug technology.
- Safety and Low Side Effects
Limits radiation damage to healthy cells due to the cell-sized particle range, enhancing safety and reducing side effects.
Our Services
Our services encompass every aspect of BNCT therapy development, from boron compound synthesis to in vivo efficacy studies, with a strong focus on precision, safety, and regulatory compliance.
Workflow of Boron Neutron Capture Therapy Development
10B Compound Design and Synthesis
Choosing an appropriate 10B-containing source, such as boride, and coupling it with a tumor-specific targeting molecule-such as an antibody, small molecule, or ligand-ensures efficient accumulation of the compounds within tumor cells.
- Target-Specific Boron Delivery
- Chemical Modifications
- Optimized Boron Carrier Selection
Neutron Irradiation Testing
This phase ensures the 10B compounds perform effectively under neutron beam exposure, with a focus on achieving precise targeting and optimal dose delivery.
- Controlled Neutron Source Access
- Dose Optimization
- High-Precision Targeting
In Vitro Preclinical Research Services
Thorough screening processes are essential to evaluate the effectiveness and safety of 10B compounds.
In Vivo Preclinical Research Services
Evaluating both the in vivo therapeutic effectiveness and potential toxic effects of BNCT is crucial to ensure pharmaceutical safety and efficacy.
Our Platform and Capabilities
To meet the high demand in BNCT research and development, Alfa Cytology leverages state-of-the-art technologies and laboratory infrastructure.
High-Resolution Imaging Systems
Imaging platforms, like PET/CT and MRI, offer highly detailed monitoring of boron distribution and tumor targeting in in vivo models.
Specialized Radiochemistry Lab
We have the dedicated infrastructure for boron compound synthesis and provide all safety precautions for safe handling and precise modification of boron agents.
Distribution and Pharmacokinetic Analysis Tools
Analytical instruments allow for accurate biodistribution studies and pharmacokinetic profiling that optimize the delivery of boron agents to target cells.
Dosimetry Software Driven by Data
Advanced dosimetry software has allowed us to generate detailed microdosimetry models. These are an essential step toward predicting preclinical outcomes of BNCT.
To learn more about Alfa Cytology's BNCT development services and how we can support your research goals, contact us today. We are committed to advancing preclinical development through innovative and reliable BNCT solutions tailored to the unique needs of your project.
Reference
- Shimizu S, Nakai K, Li Y, et al. (2023) Boron Neutron Capture Therapy for Recurrent Glioblastoma Multiforme: Imaging Evaluation of a Case With Long-Term Local Control and Survival. Cureus. 15(1): e33898.
For research use only. Not intended for any clinical use.
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