Dosimetry Services for Radiopharmaceuticals
Rdcthera expertise is in the latest contract research organization services in subserving the requirements unique to radiopharmaceutical development. We have in-depth knowledge of dosimetry services, providing accurate, trustworthy, and detailed data that will move our clients' radiopharmaceutical projects forward.
The MIRD Principle and the Importance of Dosimetry
Dosimetry is one of the keystones in radiopharmaceutical development, ensuring that the therapeutical and diagnostic applications are safe and effective. The dosimetry calculations we offer are based on the MIRD principle and achieve a very accurate quantification of the radiation dose distribution in biological tissues, an issue important to be considered for the optimization of the therapeutic efficacy while minimizing adverse effects.
Fig.1. General workflow for RPT dosimetry. (O'Donoghue J, et al., 2022)
Comprehensive Dosimetry Services
Rdcthera provides end-to-end dosimetry services tailored to meet all kinds of diverse client needs. These services will range from preliminary computations to final detailed analysis with reporting in the dosimetry workflow.
- Pharmacokinetic Modelling of In Vivo Data
We are second to none in pharmacokinetic modeling from in vivo data and deduce accurate time-activity curves. It involves sophisticated algorithms and models explaining radiopharmaceutical behavior inside the body, bringing out important information on distribution, metabolism, and elimination.
- Biodistribution and Organ Concentration Studies
Our biodistribution studies provide critical insight into radiopharmaceutical concentration in organs as a function of time. Such studies helped in understanding the pharmacokinetics and pharmacodynamics of radiopharmaceuticals, which is very useful in optimizing dosing regimens.
- Small Animal SPECT/PET Quantitative Imaging
Determination of TAC in source organs by preclinical SPECT or PET can reduce the number of animals required to perform experiments. High-resolution quantitative in vivo imaging underpins the commercialized imaging services offered with state-of-the-art SPECT and PET imaging technologies. Therefore, these imaging services are critical for the visualization and quantification of the distribution of radiopharmaceuticals to perform in-depth analysis in in vivo behavior.
- Voxel-Based Dosimetry Models
Voxels provide high-resolution dosimetry models for us. The subdivision of the body into small three-dimensional units allows us to calculate the dose accurately by accounting for the complex anatomy and tissue heterogeneity.
- Small-Scale Dosimetry Models
Besides voxel-based models, small-scale dosimetric models of specific applications and study designs are also provided. Such models, dedicated to meet specialized research requirements, offer flexibility and precision.
Why Choose Rdcthera?
Rdcthera teamed up with experts to further research in radiopharmaceuticals. State-of-the-art technology backs our full range of dosimetry services, together with robust scientific methodologies and commitment to quality and accuracy. We work to offer our clients reliable data, exceptional service delivery, and tailored innovative solutions that answer their unique needs.
Looking for more than just testing - is real science, and precision dosimetry behind radiopharmaceutical research? Contact us us today to discuss your project requirements and learn more about how Rdcthera can help support development goals.
Reference
- O'Donoghue J, Zanzonico P, Humm J, Kesner A. (2022). Dosimetry in Radiopharmaceutical Therapy. J Nucl Med. 63(10):1467-1474.
For research use only. Not intended for any clinical use.
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