Flow Cytometry
Rdcthera is a preclinical contract research organization specializing in radiopharmaceutical research. We provides comprehensive flow cytometry services designed to support the complex demands of radiopharmaceutical development.
Flow Cytometry in Radiopharmaceutical Research
Flow cytometry is a powerful analytical tool used in the evaluation of the physical and chemical characteristics of cells or particles in suspension. In general, the use of flow cytometry in radiopharmaceutical research led to applications in the monitoring of cellular responses, the study of heterogeneous cell populations, and the characterization of surface and intracellular molecules at the flow cytometry scale. This technology further elucidates details on the effects brought about by radiopharmaceuticals in the view of developing advanced therapies that are more effective with better safety margins.
Fig.1. Gating strategy of flow cytometry analysis used to identify CD206+ macrophages in human kidney tissues. (Li Z, et al., 2023)
Our Flow Cytometry Services
Rdcthera is a one-stop flow cytometry service for radiopharmaceutical research with tailor-made needs. In our services, coverage includes all facets of sample preparation, data acquisition, and very intricate analyses, yielding quality results in the pursuit of your research objectives.
Radioactive Sample Analysis Services
Our radioactive sample analysis services are designed to help overcome the challenges of working with radiolabeled compounds. At our laboratories, we provide safe and efficient radioactive sample analysis in compliance with all applicable current regulatory standards that deliver accurate and reproducible data.
Our immunophenotyping services include detailed characterization of the cell population by identifying specific cell types based on surface or intracellular markers, which is critically important for understanding immune responses and radiopharmaceuticals' impact on various cell types.
Receptor occupancy studies play a very important role in the drug-target interaction of radiopharmaceuticals. We provide accurate quantification of receptor occupancy, enabling an in-depth study of drug-receptor interactions to optimize therapeutic efficacy.
We are offering a complete spectrum of functional assays within the assessment tests—that is, determination of the biological activity of the studied radiopharmaceuticals. The studies highlight the cellular functions: proliferation, apoptosis, and cytokine production that are critical data in the evaluation of drug effects and potential toxicities.
Expression Profiling Services
Rdcthera's expression profiling services provide information about changes in gene and protein expression. It will thus allow one to identify biomarkers of disease, study cellular responses, and elucidate mechanisms of action behind radiopharmaceuticals.
Custom Services and Panel Development
Each research project has different requirements. Custom services and options for panel development enable tailored solutions to meet your specific research needs. Our capabilities include:
| Customized Options |
Applications |
| Flexible Labeling Panels |
Custom panels based on defined requirements for any particular experiment. |
| Spectral Flow Cytometry |
Techniques for advanced multiplexing and resolution enhancement. |
| FACS Analysis and Statistical Support |
Fluorescence-activated cell-sorting expertise and strong skills in statistical analysis. |
| Pre-Enrichment by Magnetic Separation |
Effective separation of the target cells to make the assessment results more accurate. |
| Dynamic Evaluations |
Real-time assessment of cellular response in presence of several conditions. |
Looking to move forward with your radiopharmaceutical research at the power of our flow cytometry services? Contact us today to discuss your project needs and learn how Rdcthera can fuel your research.
Reference
- Li Z, Zimmerman KA, Cherakara S, et al. (2023). A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models. Dis Model Mech. 16(1):dmm049810.
For research use only. Not intended for any clinical use.
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