Metabolite Analysis Services for Radiopharmaceuticals
At Rdcthera, we have enviable expertise in CRO services that cater to all the special requirements radiopharmaceuticals may have. Our in vitro metabolite analysis services are specifically designed for developing and optimizing radiopharmaceuticals in aspects of safety, efficacy, and compliance. Having seasoned scientists powered by state-of-the-art equipment and cutting-edge technologies, Rdcthera is hell-bent on ensuring that the advancement of radiopharmaceuticals finds a foothold on the pedestal of robust and precise metabolite analysis.
Overview of Radiopharmaceutical Metabolism
Metabolic pathways of radiopharmaceuticals are keys to their function and safety. Metabolite analysis gives insight into possible routes of metabolism that the radiotracer may follow in vivo. This should therefore be done to validate the choice of labeling position, such as in brain tracers where the radionuclide should stay within hydrophilic metabolites. This metabolite analysis identifies points of weakness in the tracer structure, where refinement is needed to enhance its stability and efficiency.
Fig. 1. Metabolite analysis process. (Chen Y, et al., 2022)
Our Metabolite Analysis Services
At Rdcthera, we offer end-to-end metabolite analysis services for radiopharmaceuticals. These main studies in metabolic pathways will be realized in organs responsible for the metabolism of the tracer in target tissue/cell populations themselves or within cell cultures and tissue homogenates. All these processes provide very important information about the status and fate of tracers.
- Metabolic Pathway Identification - Deeper investigations on the metabolic pathway maps of radiopharmaceuticals in various organs/tissues, with a particular focus on liver and target cells.
- Cell Culture and Tissue Homogenate Assays - Use cell culture and tissue homogenates to study the metabolic stability and transformation of radiotracers.
- Metabolite Profiling - This provides modern techniques for profiling metabolites from their parent compounds; hence, the result will be highly accurate and valid.
- Stability Testing - Investigation of the in vitro metabolic stability of radiopharmaceuticals under different conditions to identify possible degradation products and optimize formulation.
Analysis Methods
State-of-the-art analytic techniques distinguish the tracers from their metabolites. Good care is taken to account for the metabolic decay of the tracer and eliminate possible interfering factors. The rigor of the approach ensures that the metabolic data generated are both reliable and accurate.
- Chromatographic Techniques (HPLC, LC-MS)
- Radio-TLC and Radio-HPLC
- Spectroscopic Methods (NMR, UV-Vis, and mass spectrometry)
Data and Insights
Clients can look forward to getting information, data, and insights into our metabolite analysis, which will provide details on metabolic transformations the tracers take, possible weaknesses of structures, and their postmetabolic fate. Such insights should be crucial in the development of safe and effective diagnostic and therapeutic radiopharmaceutical formulations.
- Metabolic Pathway Maps
- Metabolite Profiles
- Stability Reports
- Functional Insights
Applications of In Vitro Metabolite Analysis
Metabolite analysis will find extensive application in radiopharmaceutical development. The study of metabolic pathways will be very instrumental in the structural optimization of tracers, their in vivo stability assessment, and proof of the safety and efficacy of those molecules. Rdcthera provides metabolite analysis services as a mainstay for the advancement of research and development in this field.
Please do not hesitate to contact us if you need any further information on metabolite analysis services for radiopharmaceuticals.
Reference
- Chen Y, Li EM, Xu LY. (2022). Guide to Metabolomics Analysis: A Bioinformatics Workflow. Metabolites. 12(4):357.
For research use only. Not intended for any clinical use.
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