In Vitro Autoradiography Services for Radiopharmaceuticals
Rdcthera is a radiopharmaceutical-related contract research organization. We are focused on offering high quality in vitro autoradiography with an objective to aid our customers who work towards finding affinity and selective binding of radio-tracers, thereby helping in making major decisions related to drug development.
What is Autoradiography
Autoradiography is a technique used in visualizing the distribution patterns of radiolabeled molecules across tissues. The techniques have been very instrumental during the processes of drug development by providing information critical to pharmacokinetics and pharmacodynamics of a new drug candidate. Through in vitro autoradiography, it is better interpreted how a drug interacts with its targeted receptors, and the efficacy and the safety profiles of the drugs are evaluated.
Fig. 1. In vitro autoradiography of 18 F-radiolabeled ligands on brain slices. (Zhou K, et al., 2021)
Our In Vitro Autoradiography Services
Rdcthera offers radiopharmaceutical services starting from receptor binding studies to ligand autoradiography and distribution mapping. The team continues embracing state-of-the-art equipment and methodologies, thus ensuring accuracy and reproducibility in our results. This level of tailored approach allows us to adapt our services according to the client and project's specific needs.
- Affinity and Selectivity Binding Assessments
- Non-Specific Binding Analysis
- Recruiting Assays
- Binding and Blocking Assays
Data and Insights You Can Obtain
Through our in vitro autoradiography services, clients can obtain crucial information about the distribution, density, and affinity of radiolabeled compounds within target tissues. This data can help researchers optimize drug dosing regimens, assess target engagement, and evaluate the potential efficacy of a drug candidate.
- Binding Affinity and Selectivity Profiles
- Non-Specific Binding Levels
- Binding Site Density
- Comprehensive Pathological Insights
Our Technology Platform
We also use state-of-the-art imaging systems and software to identify, with precision and accuracy, autoradiographic images. In this regard, a technology platform like ours, using radiolabeled compounds, can come up with high-resolution maps of distribution in tissues—this allows for the full assessment of drug localization and targeting.
- High-Precision Cryosectioning Equipment
- Advanced Radiodetection Instruments
- Sophisticated Data Analysis Software
- Stringent Quality Control Protocols
Our Capabilities
Rdcthera raises the bar with advanced expertise in conducting studies in vitro autoradiography. Expertise and assets in radiopharmaceuticals and molecular imaging at Rdcthera can help elucidate the pharmacological features of drug candidates. We provide high-quality data while providing excellent customer service.
Applications of In Vitro Autoradiography
In vitro autoradiography finds applications in wide fields, including the following
- Drug Development and Screening - The evaluation of potential drug candidates.
- Target Validation and Characterization - Target interaction studies.
- Receptor Occupancy Studies
- Drug Distribution Analysis
- Pathological Research - Study of mechanisms behind diseases and biomarkers.
- Neuroscience Research - Brain functioning and its disorders.
For more information about Rdcthera's in vitro autoradiography services and how we can further support your drug development efforts, do not hesitate to contact us. We look forward to working with you on your next research project.
Reference
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Zhou K, Yang F, Li Y, et al. (2021). Synthesis and Evaluation of Fluorine-18 Labeled 2-Phenylquinoxaline Derivatives as Potential Tau Imaging Agents. Mol Pharm. 18(3):1176-1195.
For research use only. Not intended for any clinical use.
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