Histology Services for Radiopharmaceutical Ex Vivo Research

At Rdcthera, we are a preclinical CRO specializing in radiopharmaceuticals. With years of expertise in ex vivo research, we can draw upon this experience to ensure the tailoring of histology services in support of radiopharmaceutical development. We engineer our services to support and further your research goals with precision and reliability.

Histology Studies in Radiopharmaceutical Research

Histology studies are one of the cornerstones of ex vivo research in this area. Indeed, such studies have relevance to the delivery of information regarding the interaction between radiopharmaceuticals and biological tissues. This will be done by assessing the distribution, localization, and effect of radiopharmaceuticals within tissue at a cellular level. This information is critical for assessing the safety and efficacy of new radiopharmaceuticals and clarifying their mechanisms of action, so as to lead to the development of safer and more effective therapeutic agents.

Fig.1. Up-regulation in radiopharmaceutical uptake occurs with and without visible tumor cell. (Bohm-Velez, et al., 2021)

Our Comprehensive Histology Services

Our histology services are represented by a large array of techniques and expertise at one's disposal to deliver support in your research. Knowing each step needs to be individually optimized for the special needs of radiopharmaceutical study, we provide all tissue preparation, staining, and analysis work. Our experts are dedicated to the delivery of high-quality, reproducible results that drive informed decision-making in drug development.

Radioactive Tissue Handling Services

Radioactive tissues require the necessary knowledge and protocols to be handled as safely and precisely as possible. Our radioactive tissue handling services are very careful in attending to the intricacies of radiopharmaceutical studies. We ensure high-safety measures and industry-standard protocols for the protection of our staff and your research data.

Tissue Extraction and Preservation Services

Our team utilizes advanced techniques to extract tissues efficiently while minimizing degradation. We offer a range of preservation methods, including fixation and freezing, tailored to the specific needs of your study to ensure optimal sample quality.

DNA, RNA, and Protein Isolation Services

We offer accurate isolation of DNA, RNA, and proteins from tissues, further enabling detailed molecular analyses. On top of that, we use state-of-the-art techniques to ensure high yields and purity, hence enabling accurate downstream applications such as sequencing, qPCR, and protein assays.

Histochemical Staining Services

We provide histochemical staining with a complete portfolio of staining techniques that differentially dye specific components of tissue or cellular structures.

Imaging & Data Analysis Services

We provide histological imaging and data analysis services that add valuable data information for drug discovery. We use state-of-the-art imaging instruments to capture high-resolution images that provide excellent detail on tissue structure and radiopharmaceutical distribution. Our data analysis team employs advanced software tools to quantify and interpret imaging data, providing actionable insights into your research and facilitating accurate and rapid decision-making.

For more information on our histology services and how Rdcthera can advance your radiopharmaceutical research, feel free to contact us. We are ready to collaborate with you to further the boundaries of radiopharmaceutical research.

Reference

1. Bohm-Velez, et al. (2011). A clinical evaluation of breast tissue uptake of Tc99m-sestamibi as a function of injected dose. J Nucl Med. 52.

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