Biomarker Services for Radiopharmaceutical Ex Vivo Research
Identification and validation of suitable biomarkers are critical in radiopharmaceutical development to provide impetus for drug discovery and development. At Rdcthera, we are a preclinical CRO with a dedicated team to offer comprehensive services in the area of biomarkers for conducting ex vivo studies of radiopharmaceuticals.
Biomarker Discovery and Identification in Radiopharmaceutical Research
Biomarkers are critical in these ex vivo studies of radiopharmaceuticals for the realisation of molecular mechanisms, therapeutic efficacy, dose optimisation, and many other aspects. With state-of-the-art technologies and well-established methodologies, we strive to bring out a detailed analysis of your samples for accurate biomarker data generation. These insights are very critical for driving preclinical research.
Fig.1. Proposed workflow for blood and tissue biomarker development in radiopharmaceutical trials. (Kunos CA, et al., 2019)
Our Comprehensive Biomarker Services
Biomarker services at Rdcthera are designed to support a wide variety of research types. Whether you're working with our in-house studies or providing your samples, we offer standardized analysis services for each of these. Moreover, we have developed expertise in the design and validation of custom assays for specific objectives and needs of research studies.
Disease-Specific Biomarker Analysis Services
We specialize in disease-specific biomarker analyses, ensuring focused and comprehensive support for a wide spectrum of diseases. Our services are focused on preclinical research needs to provide insightful information on molecular pathways and therapeutic targets that define specific diseases, thus accelerating your projects.
Imaging Biomarker Services
Imaging biomarkers will play a key role in radiopharmaceutical development since they provide visualization and quantification of biological processes. Rdcthera offers specialized imaging biomarker services to support preclinical research and development. We integrate the most advanced imaging techniques to provide overall insights into the efficacy, distribution, and mechanism of action of drugs.
Samples
We provide full-range biomarker analysis for a wide range of samples.
We process samples from rodent models such as mice, rats, and guinea pigs to demonstrate the course of a disease and success of treatment.
We process human, mouse, rat, and avian cell cultures for studying cellular responses and biomolecular interactions.
- Diverse Biological Samples
We analyze tissues, cerebrospinal fluid, blood, plasma, serum, cell extracts, supernatants, and in vitro protein aggregates. This will present the dynamics of biomarkers in full view.
In case of need, a new method will be developed by our team for an innovative assay tailored to your requirements.
Sample Analysis Services
Our services cover a wide range of analytical techniques including standardised colorimetric, fluorimetric or luminescent detection methods for quantification and evaluation.
- Western blotting
- ELISA
- Genomics
- Proteomics
- WES
- Standard RT-PCR
- Epigenomics
- Metabolomics
- Enzymatic assays
- Quantitative real-time RT-PCR
- Transcriptomics
- GWAS
We can provide you with gene, mRNA, miRNA, protein and cytokine expression analysis services in your samples. In addition, customised assays can be set up and validated.
Data Analysis and Comprehensive Reporting Services
On completion of the analysis, our team provides detailed statistical analyses with comprehensive reports. Such reports do not only present data but also add a scientific interpretation to give you more in-depth views about your research. This data thus supports your R&D decision-making with robust scientific backing.
Feel free to contact us for more information about our biomarker services or to discuss project needs. Rdcthera is committed to the support you need to advance your drug development journey.
Reference
- Kunos CA, Capala J, Ivy SP. (2019). Radiopharmaceuticals for Relapsed or Refractory Leukemias. Front Oncol. 9:97.
For research use only. Not intended for any clinical use.
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